In Taisho-era Japan, kindhearted Tanjiro Kamado makes a living selling charcoal. But his peaceful life is shattered when a demon slaughters his entire family. His little sister Nezuko is the only survivor, but she has been transformed into a demon herself! Tanjiro sets out on a dangerous journey to find a way to return his sister to normal and destroy the demon who ruined his life.

The battle between Tanjiro, Giyu and Akaza continues. To beat Akaza, Tanjiro must use an advanced technique his father taught him—the Transparent World—which will push him beyond his limitations. Elsewhere in the Infinity Castle, Shinobu, burning with hatred, confronts Doma, the demon who killed her family. Can she take on the powerful demon by herself?